https://macrothink.org/journal/index.php/jab/issue/feedJournal of Applied Biotechnology2023-02-07T04:44:36-08:00Luke Harrisjab@macrothink.orgOpen Journal Systems<img style="float: right; padding-left: 20px; padding-right: 20px;" src="/journal/public/site/images/jab/JAB-cover.jpg" alt="" width="300" /><p><em>Journal of Applied Biotechnology</em> (JAB) is an online scholarly journal, peer-reviewed, published by Macrothink Institute. The journal encourages and publishes papers in the fields of biotechnology:</p><p>* Biotechnology in food</p><p>* Biotechnology in healthcare</p><p>* Biotechnology in environment</p><p>* Biotechnology in agriculture</p><p>* Biotechnology in diagnostics</p><p>* Biotechnology in therapeutics</p>* Innovation in biotechnology and bio-ethicshttps://macrothink.org/journal/index.php/jab/article/view/20594Evaluation of Pharmacokinetic Profile of Cirpusins®, Extract of Cyperus rotundus in Presence of Bioavailability Enhancer, BioPerine®2023-02-07T04:44:36-08:00Muhammed Majeedmail1@sami-sabinsagroup.comSarang Banisarangbani@sami-sabinsagroup.comAnjali Pandeyanjalipandey@sami-sabinsagroup.comMohammad Ansariansari@sami-sabinsagroup.comSmitha Thazhathidathsmitha@sami-sabinsagroup.com<p>Obesity, a condition accompanying abnormal or excessive accumulation of fat in the body has become a major public health concern globally. Various herbs hailed from traditional systems of medicine like Ayurveda have gained importance in recent years to combat obesity. One such herb <em>Cyperus rotundus</em> (nutgrass), is known for its beneficial effects in obesity, in Ayurveda. Cirpusins<sup>®</sup> a patented extract from the dried rhizomes of <em>Cyperus rotundus</em> (standardized for minimum of 6% total identified stilbenes - Piceatannol, Scirpusin A & Scirpusin B) and BioPerine<sup>®</sup>, a bioavailability enhancer, obtained from the dried fruits of <em>Piper nigrum</em> (standardized to minimum 95% piperine). In this study, we examined the pharmacokinetic profile and bioavailability of Cirpusins<sup>®</sup> in Sprague-Dawley rats at two different doses (45 and 90 mg/kg) in the presence and absence of BioPerine<sup>® </sup>respectively. The results signifies that addition of BioPerine<sup>®</sup> (0.45 mg/kg) with Cirpusins<sup>®</sup> (45 mg/kg) enhances the bioavailability by reducing the effective dose of Cirpusins<sup>®</sup> (90 mg/kg) to half.</p>2023-02-07T00:00:00-08:00Copyright (c) 2023 Muhammed Majeed, Sarang Bani, Anjali Pandey, Mohammad Ansari, Smitha Thazhathidath