Journal of Biology and Life Science (JBLS; ISSN 2157-6076) is an international, peer-reviewed, online journal published by Macrothink Institute, USA. It publishes research papers, reviews, and short communications in all areas of biology and life sciences. The journal is published semiannually in February and August. Submissions are accepted online or by emaill (jbls@macrothink.org). For inquiries, please contact jbls@macrothink.org. JBLS is included in: CNKI CrossRef ERA EuroPub Genamics JournalSeek Google Scholar Citations LIVIVO (ZB MED) Mendeley OpenAgrar Open policy finder PKP Open Archives Harvester Qualis Index RePEc Technische Informationsbibliothek (TIB) WorldCat Areas include, but are not limited to: Anatomy Botany Biochemistry Biophysics Biotechnology Cytology Developmental Biology Ecology Genetics Aquatic Biology Microbiology Molecular Biology Neurobiology Physiology Zoology Authors are invited to submit original, unpublished manuscripts not under consideration elsewhere. The journal is published as an open-access online journal, with articles freely accessible and downloadable in PDF format.
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Application of Multimodal Sensing Technology in Smart Monitoring and Nursing Process Reengineering in the NICU
To explore the application effectiveness of an intelligent monitoring system based on multimodal sensing technology (flexible sensors, smart central processing platform, mobile medical smart terminals) in the neonatal intensive care unit (NICU) and evaluate its impact on nursing workflow restructuring, a prospective randomized controlled study was conducted. A total of 120 preterm infants admitted to the NICU of a Level-A Tertiary Hospital (the highest level in China) from January to December 2024 were randomly assigned to an observation group (n=60) and a control group (n=60). The control group received conventional wired monitoring and routine care, while the observation group utilized a multimodal intelligent monitoring system comprising flexible sensors, a smart central processing platform, a medical mobile smart terminal (PDA), and environmental sensors. The study compared the following outcomes between groups: timely identification rate and effective alarm rate of clinical events (e.g., respiratory or cardiac abnormalities), nurse response time, daily nursing documentation time, nurse activity trajectory analysis for work efficiency, and nurse workload (assessed using the NASA-TLX scale). The results showed that the observation group’s timely clinical event recognition rate and effective alarm rate were both significantly higher than the control group's (P < 0.001). Both of the observation group's response time to alarm events and average daily nursing documentation time for nurses were significantly shorter than those in the control group (P < 0.001). The number of trips nurses made to the nursing station for documentation decreased significantly in the observation group compared to the control group, markedly improving work efficiency. Besides, the observation group's NASA-TLX scores were superior to the control group across all dimensions (P < 0.05). Conclusions can be drawn as the multimodal intelligent monitoring system accurately monitors neonatal vital signs, significantly enhances the timely identification rate and effective alarm rate of clinical events in the NICU, markedly reduces nurse response time, and substantially shortens the time nurses spend on documentation. It reconfigures the NICU's efficient nursing workflow centered on patient care and early warning, thereby improving nursing quality and ensuring patient safety, demonstrating significant clinical application value.
Copyright (c) 2025 Qin Liu http://creativecommons.org/licenses/by/4.0
Exploration and Practice of the “Modular Challenge-Based” Teaching Model in Pediatric Internship Nursing Education: Taking Pediatric Fever-Induced Seizures as an Example
To investigate the effectiveness of the “modular challenge-based” model in pediatric nursing internships for febrile seizures, nursing students undergoing pediatric internships at Deyang People's Hospital, Sichuan Province, China, were selected as subjects from July 2024 to July 2025. Using a random number table, they were divided into a control group and an experimental group, each comprising 37 interns. The control group received traditional nursing education on pediatric febrile seizures, while the experimental group received teaching using the “modular challenge-based” model for pediatric febrile seizures. The effectiveness of the two teaching approaches was compared and results showed that the experimental group's scores on the Self-Directed Learning Ability Evaluation Scale, the experimental group's scores on the Clinical Decision-Making Nursing Skills Assessment (CDMNS), the experimental group's teaching satisfaction scores, and the experimental group's theoretical examination scores at the end of the rotation were all significantly higher than the control group's (P < 0.05). Therefore, conclusions could be drawn as the “modular challenge-based” model could effectively enhance nursing students' self-directed learning abilities when studying pediatric febrile seizures. It improves clinical decision-making skills and teaching satisfaction while deepening theoretical knowledge mastery, making it worthy of clinical implementation in a larger scale and a deeper realm.
Copyright (c) 2025 Tingting Li, Yu Wang http://creativecommons.org/licenses/by/4.0
A Study on the Effects of Preoperative Visits Led by Operating Room Nurses on Patients' Anxiety Levels and Postoperative Recovery Satisfaction
To investigate the effects of a standardized preoperative visitation model led by operating room nurses on alleviating preoperative anxiety levels and enhancing postoperative recovery satisfaction among elective surgery patients, a prospective randomized controlled study design was employed in which two hundred patients scheduled for elective surgery at a city-based hospital between June 2024 and May 2025 were enrolled. Using a random number table, they were divided into an intervention group (n=100) and a control group (n=100). The control group received routine preoperative preparation by ward nurses. while the intervention group additionally received standardized preoperative visits led by uniformly trained operating room nurses. Anxiety levels were assessed using the State-Trait Anxiety Inventory (S-TAI) at two time points: before the visit (T0) and after entering the operating room while calmly resting in bed (T1). Patient satisfaction was evaluated using the Newcastle Nursing Service Satisfaction Scale (NSNS) prior to discharge (T2). Results showed that at baseline (T0), no significant difference existed in S-TAI scores between groups (P>0.05). At T1, the intervention group's S-TAI score (42.1±5.3) was significantly lower than the control group (51.8±6.1) (t=8.24, P<0.001). At T2, the intervention group's NSNS total score and all dimension scores were significantly higher than the control group (P<0.001). Conclusions could be drawn as the standardized preoperative visit led by operating room nurses effectively alleviates patients' preoperative anxiety and significantly enhances their overall satisfaction with the postoperative recovery process. This model is recommended for promotion and application as a high-quality nursing practice in perioperative care in China and beyond.
Copyright (c) 2025 Jing Wang http://creativecommons.org/licenses/by/4.0
Application of an ITHBC-Based Self-Management Intervention Program for Inflammatory Bowel Disease Patients
To explore the effectiveness of an ITHBC-based self-management intervention program for patients with inflammatory bowel disease (IBD), Eighty IBD patients who visited the Gastroenterology Department of a tertiary hospital in mainland China between July and December 2024 were enrolled. Participants were numbered sequentially based on their admission order and randomly assigned to either the control group (n=40) or the intervention group (n=40) using a random number table. The control group received standardized clinical pathway treatment and routine nursing care, while the experimental group received care based on the IBD self-management intervention protocol. The study compared the effects of these two interventions on patients' self-management capabilities, clinical symptom relief, and readmission rates. Results showed that Pre-intervention scores on the IBD Self-Management Behavior Scale exerted no significant difference between groups (P > 0.05); In Post-intervention, the experimental group demonstrated significantly higher scores than the control group (P < 0.05); Pre-intervention SCS-IBD scores showed no significant difference between groups (P > 0.05); In Post-intervention, trial group SCS-IBD scores were significantly lower than control group scores (P < 0.05). The rehospitalization rate in the intervention group was significantly lower than that in the control group after the intervention (P < 0.05). In Conclusion, the IBD self-management intervention program based on the ITHBC theory not only effectively improved self-management behaviors in IBD patients but also efficiently alleviated clinical symptoms and reduced rehospitalization rates, which fully validated the effectiveness of the theoretical model and provided a reference paradigm for the theoretical construction of subsequent chronic disease intervention programs in the near future.
Copyright (c) 2026 Yulan Jia, Yao Zeng, Lisha Wang, Xixi Xie, Ni Zeng http://creativecommons.org/licenses/by/4.0
An Empirical Study on the Combined Application of the DEDICT Teaching Model and Scenario Simulation Among Operating Room Nursing Interns
Objective: Discuss the effect of the DEDICT teaching mode combined with scenario simulation among operating room nursing interns. Methods: We selected 110 nursing interns in our hospital's operating room between October 2024 and September 2025. We randomly assigned them to a control group or an experimental group using a random number table. The control group received conventional teaching, while the experimental group underwent DEDICT teaching combined with scenario simulation. We compared the Theoretical and Practical Performance Scores, the Nursing Staff's Self-Directed Learning Ability Scores, the Nursing Competency Scores, and the Teaching Effectiveness Satisfaction Evaluation between the groups. Results: The Theoretical and Practical Performance Scores in the experimental group were 92.16 ± 7.22 and 94.36 ± 3.15, significantly higher than those of the control group at 83.24 ± 6.35 and 82.17 ± 4.54. The experimental group demonstrated higher Nursing Staff's Self-Directed Learning Ability Scores (147.19 ± 12.34 vs. 137.65 ± 11.55) and Nursing Competency Scores (192.54 ± 32.37 vs. 170.83 ± 39.64) than the control group, with all differences being statistically significant (P < 0.05). The Teaching Effectiveness Satisfaction Rate in the experimental group was 98.18%, exceeding that of the control group (89.09%). The rank-sum test yielded Z = -2.475, P =0.014. Conclusions: The application of the DEDICT teaching model combined with scenario simulation enhances nursing interns' theoretical and practical performance, improves their autonomous learning capabilities, elevates their job competency, and facilitates their adaptation to clinical nursing work more effectively and expeditiously. This approach is of significant importance to nursing education and warrants further implementation.
Copyright (c) 2026 Peijun Xiang, Ping Lai, Zhuqing Chen, Zhaohua Zou http://creativecommons.org/licenses/by/4.0
A Machine Learning Approach for Predicting Failed First-Attempt Radial Artery Puncture Patients with Heart Failure
Objective: To identify risk factors for first-attempt failure of radial arterial puncture in heart failure patients and to develop and compare predictive models using logistic regression with advanced feature engineering and ensemble learning approaches. Method: A retrospective study was conducted involving 789 heart failure patients who underwent radial arterial puncture. Patients were divided into a training set (80%) and a test set (20%) using a stratified hold-out method. A logistic regression framework incorporating feature engineering (interaction terms, transformations, composite scores, PCA) and a dual-stage variable selection strategy (LASSO followed by stepwise selection with p<0.1 threshold) was employed. Four ensemble models were developed in parallel. Model performance was evaluated using area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and calibration metrics through a multi-repeat validation framework. Results: The final logistic regression model identified eleven variables, with edema degree (β = -0.0959, OR = 0.9085, p = 0.0160) and the interaction between ejection fraction and log-transformed BNP (β = 0.1507, OR = 1.1627, p = 0.0371) reaching statistical significance. The model demonstrated fair discriminative ability with an average test AUC of 0.693 (±0.033), high specificity (95.59% ± 2.55%), but lower sensitivity (31.88% ± 13.98%). The ensemble learning models showed weaker discriminative performance but exhibited potential overfitting on the training set. The optimal probability cutoff for the logistic model was 0.658. Conclusion: Both modeling approaches developed effective prediction tools. The logistic regression model provided clinically interpretable risk factors, while the ensemble learning models achieved higher discriminatory power at the cost of interpretability. These models can assist in pre-procedural identification of high-risk patients, allowing for tailored strategies to improve first-attempt success rates and reduce patient discomfort.
Copyright (c) 2025 Huan Wang, Jiangbo Zhang http://creativecommons.org/licenses/by/4.0
Structured Emergency Drills Enhance Core Disaster Nursing Competencies and Preparedness Among Emergency Department Nurses: A Multicenter Prospective Cohort Study
To investigate the effectiveness of structured emergency drills in enhancing core disaster nursing competencies and preparedness among emergency department nurses, this multicenter prospective cohort study enrolled 178 nurses from four tertiary-level Class A hospitals (the top-tier ones in mainland China) in a city between January and December 2024 and quarterly structured practical emergency drills were implemented as an intervention. Meanwhile, Standardized assessment tools were administered at baseline and at the end of each quarter. Results showed that both the total score for core disaster nursing competencies and the total disaster preparedness score rose significantly in respective, from 122.8 ± 14.2 at baseline to 179.2 ± 12.6 in the fourth quarter (P < 0.001), and from 80.4 ± 10.8 to 118.9 ± 9.7 (P < 0.001). Multivariate regression analysis revealed that professional title (β=0.214, P=0.008), disaster training experience (β=0.186, P=0.016), and years of service (β=0.172, P=0.025) significantly influenced core competency improvement. Conclusions could be drawn as the structured practical emergency drills significantly enhance core disaster nursing competencies and preparedness among emergency department nurses, establishing an effective disaster response training model.
Copyright (c) 2026 Hairong Wang http://creativecommons.org/licenses/by/4.0
Analysis of the Combined Screening Value of Glycated Hemoglobin and Fasting Blood Glucose in Community-Based Geriatric Health Checkups
To evaluate the value of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) for diabetes screening in community-dwelling elderly population, both individually and collectively, and thereby providing evidence for optimizing early diabetes screening strategies in community health checkups, 200 elderly residents aged ≥65 years who underwent annual health examinations at the Southeast Community Health Service Center of Deyang City, Sichuan Province, China from January to December 2025 were enrolled. All participants underwent HbA1c and FPG testing. Using the oral glucose tolerance test (OGTT-2hPG ≥ 11.1 mmol/L) as the golden standard for diabetes diagnosis, we calculated and compared the sensitivity, specificity, Youden index, and area under the receiver operating characteristic curve (AUC) for FPG, HbA1c, and their combined screening. Results showed that among the 200 subjects, the diabetes detection rate via OGTT was 16.5% (33 cases), and HbA1c screening (cutoff 6.2%) demonstrated a sensitivity of 81.8%, significantly higher than FPG screening (cutoff 6.1 mmol/L) at 66.7%, but its specificity (89.8%) was slightly lower than FPG (94.0%). Among them, the series combination yielded the highest specificity (98.2%), while the parallel combination achieved the highest sensitivity (93.9%). The AUC was 0.927, indicating significantly superior screening performance compared to single tests. The Youden index suggested the parallel combination as the optimal strategy. In conclusion, in community-based geriatric health examinations, glycated hemoglobin could serve as an effective diabetes screening indicator. The parallel combination of glycated hemoglobin and fasting plasma glucose might significantly enhance screening sensitivity, reduce missed diagnoses, and would be suitable for large-scale screening in community-dwelling elderly population.
Copyright (c) 2026 Qian Pan http://creativecommons.org/licenses/by/4.0
The Effect of Empathetic Nursing Combined with Family-Participatory Nursing on Psychological Stress Responses in Critically Ill Patients in the Emergency Department
To investigate the effects of empathetic nursing combined with family-participatory nursing on psychological stress responses in critically ill patients in the emergency department, 96 critically ill patients admitted to the emergency department of a tertiary A-level hospital in mainland China between April 2025 and April 2026 were enrolled. Participants were evenly divided into a control group and an observation group based on admission sequence in respective, with 48 patients in each group. The control group received traditional nursing interventions, while the observation group received empathetic nursing combined with family-participatory nursing. The effects of these two nursing interventions on patients' psychological status, post-traumatic stress disorder (PTSD), and patient satisfaction were compared. Results illustrated that in pre-intervention period, both SAS & SDS scores and IES-R scores showed no significant difference between groups (P > 0.05); while in post-intervention era, observation group patients exhibited significantly lower SAS & SDS scores and IES-R scores than control group counterparts (P < 0.05). Meanwhile, patient satisfaction survey scores were significantly higher in the observation group (P < 0.05). In conclusion, empathetic nursing combined with family-participatory care could offer a novel pathway for humanistic care in critically ill emergency department patients. This approach could not only effectively improve psychological status and post-traumatic stress disorder symptoms in critically ill emergency patients, but also enhance patient satisfaction, and thus warrant clinical implementation in depth on a larger scale.
Copyright (c) 2026 Xue Yang http://creativecommons.org/licenses/by/4.0
Population Structure and Growth Dynamics of the Mangrove Oyster Crassostrea tulipa in the Casamance Estuary (Senegal)
The mangrove oyster Crassostrea tulipa is an important ecological and fishery resource in West African estuaries, but information on its population dynamics remains limited in inverse estuarine systems. This study examines the population structure, growth, and natural mortality of C. tulipa in the Bliss Kassa Islands of the Casamance Estuary (southern Senegal), an environment characterized by strong spatial and seasonal variability in salinity. Oyster sampling was conducted monthly from December 2021 to November 2023 at three sites (Diogue, Hitou, and Niomoune) distributed along a downstream–upstream gradient. Water temperature and salinity were measured concurrently during each sampling campaign. Size–frequency analysis showed clear spatial differences in population structure. Diogue was dominated by small-sized individuals, indicating high recruitment and strong post-recruitment mortality, whereas Hitou exhibited a wider size range, including large oysters exceeding 70 mm. Niomoune populations were mainly composed of intermediate-sized individuals. Three overlapping cohorts were identified over the study period, suggesting continuous or multi-modal recruitment. Growth parameters were estimated from size–frequency data using the von Bertalanffy growth function. Asymptotic shell length (L∞) ranged from 48.49 to 57.80 mm, and growth coefficients (K) from 0.222 to 0.367 yr⁻¹. These values indicate relatively slow growth compared with other West African populations. Natural mortality (M), estimated using Pauly’s empirical model, varied between 0.565 and 0.746 yr⁻¹. M/K ratios indicated intermediate life-history strategies across sites. However, the truncated size structure observed at Diogue suggests additional mortality sources, likely related to harvesting pressure. The results highlight the combined influence of local hydrological conditions and anthropogenic pressure on the population dynamics of C. tulipa in the Casamance Estuary. Site-specific management measures, including minimum harvest sizes and mangrove habitat protection, are recommended to support sustainable exploitation of this resource.
Copyright (c) 2026 Mamadou Lamine Fanné, Babacar Sané, Jeanne Elisabeth Diouf, Nicola Gueye Mbengue, Malick Diouf http://creativecommons.org/licenses/by/4.0
Morphology and Morphometry Analysis of Toxic Brachyurans from Nglolang Beach, Gunungkidul
Toxic crabs from the families Xanthidae and Eriphiidae pose health risks due to variable toxicity influenced by diet, habitat, and environmental conditions. Xanthidae species are known to contain neurotoxins such as tetrodotoxin (TTX) and saxitoxin (STX), which can cause paralysis and poisoning in humans, whereas Eriphiidae crabs generally exhibit lower but more consistent toxin levels. Although toxic crab species have been reported across the Indo-Pacific, applied morphometric studies at local coastal scales remains limited. Thus, this research aims to characterize morphometric features of toxic Xanthidae and Eriphiidae crabs at Nglolang Beach to support species identification and risk awareness. This study was conducted at Nglolang Beach, Gunungkidul, using purposive sampling method in the intertidal zone with concurrent measurement of water temperature and salinity. Collected specimens were anesthetized, photographed, morphologically identified, and preserved in a 70% alcohol-glycerin solution at a 9:1 ratio. This study aims to characterize morphometric features of toxic Xanthidae and Eriphiidae crabs at Nglolang Beach to support species identification and risk awareness. Four toxic species were identified: Eriphia scabricula, Atergatis floridus, Etisus laevimanus, and Platypodia granulosa. These species display measured morphometric parameters, including chela dimensions and carapace surface texture, which are associated with intertidal survival. Environmental factors, particularly temperature and salinity, were observed to influence crab activity. By providing region-specific morphometric data for known toxic taxa, this study supports coastal biodiversity documentation, public safety, and sustainable tourism. Notably, crab toxins may persist after cooking, posing a continued risk if consumed.
Copyright (c) 2025 Dhea Amelia, Jagad Wenang Suryoaji, Alisha Syavitri Ramadhani Arbian, Ridhwan Putra Ramadhan, Asy Syifa Paras Ceria, Rury Eprilurahman http://creativecommons.org/licenses/by/4.0
Research into the Construction and Application Effectiveness of a Job Competency Training System for Geriatric Care Personnel Based on the “Medical-Educational Integration” Model
To establish a standardized competency training system for geriatric care personnel based on the “medical-educational integration” model and evaluate its effectiveness in enhancing job competency, a mixed-methods research design was employed as following. First, the status quo of job competency and training needs among geriatric care personnel in Deyang City (a major city in southwestern China) were systematically analyzed through literature review, questionnaire survey (n=360), semi-structured interviews, and expert consultation. Second, guided by the “integration of medical and educational resources” philosophy, a standardized training system covering three dimensions— “knowledge, skills, and emergency response”— was developed in collaboration with hospitals, academic institutions, and elderly care industry associations. An “Intelligent Industry-Academia-Research Training Platform for Elderly Health Care” was henceforth established. Finally, 120 caregivers underwent a 6-month systematic training program. A pre-post self-comparison design was employed to assess differences in theoretical knowledge, operational skills, emergency response capabilities, and professional value perception before and after training. Results showed baseline surveys revealed that caregivers were predominantly female (78.5%), with 73.5% holding a high school diploma or lower. Awareness of emergency care stood at only 18.3%, while knowledge of rehabilitation care was a mere 12.5%. Post-training, theoretical knowledge, operational skill, professional value perception and emergency response capability scores all increased, from (65.3 ± 12.1) to (86.7 ± 8.5) points (P < 0.001); (58.6 ± 14.3) to (82.4 ± 9.2) points (P < 0.001); (42.5 ± 15.6) to (78.9 ± 11.3) points (P < 0.001); (3.2 ± 0.8) to (4.1 ± 0.6) points (on a 5-point scale, P < 0.001) respectively. Training satisfaction reached 92.5%. In conclusion, the competency training system for geriatric care personnel, developed based on the “medical-educational integration” model, could significantly enhance caregivers' professional knowledge, skill proficiency, emergency response capabilities, and occupational identity. This approach represents an effective pathway to improve regional elderly care service quality.
Copyright (c) 2026 Jing Xu http://creativecommons.org/licenses/by/4.0
Analysis of Factors Influencing Early Discharge in Patients Undergoing Knee Replacement Surgery Under the ERAS Protocol: A Single-Center Retrospective Cohort Study
To investigate independent factors influencing early discharge (hospital stay ≤3 days postoperatively) among patients undergoing primary unilateral total knee arthroplasty (TKA) under the Enhanced Recovery After Surgery (ERAS) pathway, a retrospective cohort study design was employed in which a total of 316 patients who underwent ERAS pathway TKA in the Department of Orthopedics, Deyang People's Hospital, a Grade A Class 3 hospital (the top tier hospital in mainland China) from January 1, 2024, to December 31, 2025, were consecutively enrolled. In this study, patients were divided into an early discharge group (n=142) and a conventional discharge group (n=174) based on whether patients’ postoperative hospital stay was ≤3 days. Patient demographics, preoperative comorbidities and laboratory values, intraoperative data, and postoperative recovery indicators were all collected. Univariate analysis compared group differences, and statistically significant variables were included in a multivariate logistic regression model to identify independent factors influencing early discharge. Results showed: multivariate logistic regression analysis revealed that age <70 years (OR=2.41, 95% CI: 1.42-4.10), preoperative hemoglobin ≥130 g/L (OR=1.98, 95% CI: 1.18–3.33), intraoperative blood loss <100 ml (OR=2.85, 95% CI: 1.65–4.91), and those achieved ambulation within 24 hours postoperatively (OR=3.72, 95% CI: 2.14–6.48), and visual analog scale (VAS) score <4 on postoperative day 1 (OR=2.26, 95% CI: 1.31–3.89) were independent factors promoting early discharge. In conclusion: Under the ERAS pathway, early discharge in TKA patients is influenced by multiple factors. Optimizing preoperative patient status, refining surgical techniques to minimize trauma, and enhancing postoperative pain management and early rehabilitation are key to achieving safe early discharge. Identifying these factors assists clinical care teams in conducting precise preoperative assessments and perioperative management.
Copyright (c) 2026 Wei Luo http://creativecommons.org/licenses/by/4.0
A Study on the Effectiveness of Positive Psychological Intervention Based on the PERMA Model in Postpartum Depression and Breastfeeding Self-Efficacy Among Primiparous Women
To examine the effects of a positive psychological intervention based on the PERMA model on postpartum depression and breastfeeding self-efficacy among primiparous women, providing evidence-based support for optimizing postpartum care interventions, a prospective randomized controlled trial was conducted in a tertiary hospital in southwest part of China. A total of 120 primiparous women who delivered at the Obstetrics Department between January and June 2025 were randomly assigned to either an intervention group (n=60) or a control group (n=60). The control group received routine postpartum care, while the observation group additionally underwent an 8-week PERMA-based positive psychological intervention (comprising 5 modules: positive emotion cultivation, engagement experiences, relationship building, meaning pursuit, and achievement documentation). Assessments were conducted using the Edinburgh Postnatal Depression Scale (EPDS) and the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) at 3 time points: pre-intervention (T0), 4 weeks post-intervention (T1), and 8 weeks post-intervention (T2). Results showed that at 8 weeks post-intervention, the observation group exhibited lower EPDS scores (7.32 ± 2.15) than the control group (10.68 ± 3.42), while the BSES-SF score (58.46 ± 6.83) was higher than that of the control group (48.72 ± 7.95). Both differences were statistically significant (t = −6.384, 7.216; P < 0.001). The exclusive breastfeeding rate at 8 weeks postpartum was higher in the observation group (68.3%) than in the control group (45.0%), with statistically significant differences (χ²=6.736, P=0.009). Repeated measures ANOVA revealed statistically significant time effects, between-group effects, and interaction effects for both EPDS and BSES-SF scores across groups (P<0.05). In conclusion, positive psychological intervention based on the PERMA model could effectively alleviate postpartum depression in primiparous women, enhance breastfeeding self-efficacy, and increase exclusive breastfeeding rates. Its application in postpartum care is highly recommended in a larger scale in China and across the globe.
Copyright (c) 2026 Yanran Wu, Jun Yin, Chunyan Xu http://creativecommons.org/licenses/by/4.0
Implementation of Clinical Nursing Interventions and Risk Management During the Transport of Critically-Ill Emergency Patients
To investigate the effectiveness of a clinical nursing intervention combined with a risk prevention and control model in the transport of critically-ill emergency patients, a total of 220 critically-ill patients admitted to the Emergency Department of Deyang People’s Hospital (a city-based tertiary hospital in southwestern China) between February and July 2025 who required intra-hospital or inter-hospital transport were selected as study subjects. Using a random number table, they were evenly divided into a control group and an observation group, with 110 patients in each one. The control group received traditional emergency transport care, while the observation group received care based on the clinical nursing intervention combined with a risk prevention and control model. The study compared the effects of the two transport care interventions on the incidence of transport-related complications, the incidence of transport-related adverse events, and nursing satisfaction among critically-ill emergency patients. Results showed that both the incidence of transport-related complications and the incidence of transport-related adverse events in the observation group were significantly lower than those in the control group (P < 0.05); and patient satisfaction in the observation group was significantly higher than that in the control group (P < 0.05). In conclusion, the combination of clinical nursing interventions and a risk prevention and control model could accurately identify high-risk factors for transport, significantly reduce the incidence of complications and adverse events during transport, such as hypotension, tube dislodgement, and falls, and effectively mitigate transport safety risks. At the same time, through refined nursing services, efficient emergency response, and standardized handover procedures, it could also substantially improve nursing satisfaction among patients and their families, making it worthy of clinical promotion and application.
Copyright (c) 2026 Junmeng Tang http://creativecommons.org/licenses/by/4.0
Application of a Multidisciplinary Collaborative Standardized Management Process for Children's Burn Injuries Throughout Their Lifelong Mental Health
To investigate the effectiveness of a multidisciplinary, standardized, full-lifecycle mental health management process for pediatric burn and scald injuries, a total of 86 pediatric burn patients admitted to the Burn Department of a tertiary hospital in a prefecture-level city, Sichuan Province in China, between January 2025 and November 2025 were enrolled. Participants were divided into a control group (n=43) and an intervention group (n=43) based on admission sequence. The control group received conventional psychological interventions, while the intervention group received multidisciplinary collaborative, full-lifecycle mental health intervention nursing for pediatric burn injuries. The effects of both nursing interventions on children's post-traumatic stress disorder (PTSD), anxiety, depression, and parental satisfaction were compared. Results showed that before pre-intervention, there was no significant difference existed between groups in PTSD-RI scores, SCARED and CDI scores (P > 0.05). After post-intervention, the intervention group exhibited significantly lower PTSD-R, SCARED and CDI scores than the control group (P < 0.05). Meanwhile, post-intervention parental satisfaction scores were significantly higher in the intervention group (P < 0.05). In conclusion, the multidisciplinary collaborative, full-lifecycle mental health management process for pediatric burns could effectively reduce post-traumatic stress, anxiety, and depression levels through phased, differentiated interventions while enhancing parental satisfaction. This provides a comprehensive, multidimensional, and highly collaborative practice model for pediatric trauma psychological intervention, warranting clinical implementation in the future.
The Effect of Standardized Emergency Care Protocols on Door-to-Thrombolysis (DNT) Time in Patients with Acute Ischemic Stroke
To investigate the effect of standardized emergency care protocols on door-to-thrombolysis (DNT) time in patients with acute ischemic stroke, a total of 92 patients with acute ischemic stroke (AIS) who presented to the Department of Emergency at a Grade A Level III hospital (the top tier in mainland China) in Deyang City, Sichuan Province, between June 2024 and May 2025 were enrolled in this study. Patients were divided into a control group and an observation group based on the order of admission. The control group received conventional emergency nursing interventions, while the observation group received standardized emergency nursing protocols to compare the effects of the two nursing interventions on patient treatment time, neurological recovery, and post-thrombolysis complications. Results showed that in the observation group, DNT, time from admission to completion of thrombolysis assessment, time from admission to completion of the first CT scan, and total time spent on the emergency care pathway were all significantly shorter than those in the control group (P < 0.05); there was no significant difference in NIHSS scores between the two groups before thrombolysis (P > 0.05). However, NIHSS scores in the observation group were significantly lower than those in the control group 2 days and 7 days after thrombolysis (P < 0.05); the incidence of symptomatic intracranial hemorrhage, pulmonary infection, and deep vein thrombosis in the observation group was significantly lower than that in the control group (P < 0.05). In conclusion, a standardized emergency care pathway could effectively reduce treatment time for patients with acute ischemic stroke, promote neurological recovery, and lower the incidence of post-thrombolysis complications, paving ways for further studies in a wider and larger clinical settings.
Copyright (c) 2026 Yan Yan http://creativecommons.org/licenses/by/4.0
The Effects of Cycling Exercise Combined with Low-Temperature Adjustable Sodium Mode on Quality of Life and Negative Emotions in Patients Undergoing Maintenance Hemodialysis
Objective: To investigate the effects of bicycle exercise combined with low-temperature adjustable sodium mode on the quality of life and negative emotions of patients undergoing maintenance hemodialysis. Methods: Forty patients undergoing maintenance hemodialysis at our hospital were randomly assigned to two groups (n = 20 each) using a random number table. The control group received routine care, while the intervention group underwent supine bicycle exercise combined with a low-temperature adjustable sodium regimen. Depression, anxiety, quality of life, and patient satisfaction were assessed using the Depression Scale, Anxiety Scale, Quality of Life Questionnaire, and Patient Satisfaction Survey, respectively. Results: Pre-intervention depression and anxiety scores showed no statistically significant differences between groups (t= 0.712 and 0.885; P = 0.747 and 0.722). After 12 weeks of intervention, the observation group exhibited significantly lower depression and anxiety scores than the control group (t = -5.963 and -5.332; P = 0.000 and 0.000). Pre-intervention quality of life scores across all dimensions and total scores showed no statistically significant differences between groups (P > 0.05). After 12 weeks of intervention, the observation group exhibited significantly higher total quality of life scores and scores across all dimensions compared to the control group (P < 0.05). The observation group also demonstrated a statistically significantly higher overall satisfaction score compared to the control group ( P < 0.05). Conclusion: Combining bicycle exercise with a low-temperature adjustable sodium mode improves quality of life and alleviates negative emotions in patients undergoing maintenance hemodialysis, thereby enhancing their well-being.
Copyright (c) 2026 Minghao Xu, Wei Qing, Zhaohua Zou, Jiquan Zhang, Xinjie Cheng, Ruixin Peng http://creativecommons.org/licenses/by/4.0
The Impact of Hospital-Community-Home Collaborative Continuum of Care on Cognitive Function and Caregiver Burden in Stroke Patients with Cognitive Impairment
To investigate the effects of integrated hospital-community-home continuity of care on cognitive function and caregiver burden in stroke patients with cognitive impairment, a total of 104 patients with post-stroke cognitive impairment (PSCI) who were hospitalized in the Department of Neurology at a Grade A Level III general hospital (the top tier hospital in China) in Sichuan Province between October 2024 and October 2025 were enrolled in the study. Using a random number table, they were divided into a control group (n=52) and an intervention group (n=52), where the control group received conventional post-discharge care, while the intervention group received “hospital-community-home” three-tier collaborative post-discharge care. The effects of the two care interventions on patients’ cognitive function, caregiver stress, and patients’ activities of daily living were then compared. Results showed that there were no significant difference in MoCA scores, in CBI scores between the caregivers of patients and in MBI scores in the two groups at discharge (P > 0.05); however, at 3 months and 6 months post-discharge, the MoCA scores, the CBI scores, and the MBI scores of patients in the intervention group were all significantly higher than those in the control group (P < 0.05). In conclusion, “hospital-community-home” integrated continuity of care could effectively improve cognitive ability and self-care capacity in stroke patients with cognitive impairment and reduce caregiver burden, making it worthy of clinical implementation for patients’ sake.
Copyright (c) 2026 Qian Zhu http://creativecommons.org/licenses/by/4.0
Clinical Evaluation of Immediate Implantation in Molars with Chronic Apical Periodontitis and Chronic Periodontitis
To evaluate the clinical efficacy of immediate implant placement in molars affected by chronic apical periodontitis and chronic periodontitis, 50 patients admitted to a city-based southwest stomatological hospital in mainland China between July 2023 and July 2024 who required tooth extraction due to chronic apical periodontitis or chronic periodontitis and met the inclusion criteria were selected as samples. They were randomly assigned to an experimental group (Group A) and a control group (Group B), with 25 patients in each one. The experimental group underwent immediate implant placement, while the control group underwent delayed implant placement 3–6 months after extraction and all surgeries were performed by the same implant surgeon. The study compared the effects of the two treatment modalities on implant retention, complications, implant stability, surrounding soft tissue, vertical and horizontal margins, and peri-implant gaps. Results showed that at the 12-month postoperative follow-up, implant retention rates were high in both groups, with no statistically significant difference in retention rates between groups (P > 0.05). Regarding complication rates, the immediate implant group showed a significantly lower incidence than the delayed implant group, with a statistically significant difference (P < 0.05); immediately after post-operation, there was no statistically significant difference in ISQ scores between the two groups (P > 0.05). At 6 months postoperatively, ISQ scores in both groups had increased significantly compared to the immediate postoperative period, with statistically significant intra-group differences (P < 0.05). Furthermore, the ISQ score in the immediate implant group was higher than that in the delayed implant group, with a statistically significant intra-group difference (P < 0.05); at the 12-month follow-up after crown restoration, the periodontal probing depth (PD), modified sulcus bleeding index (mSBI), and modified plaque index (mPI) were all lower in the immediate implant group than those in the delayed implant group, with statistically significant differences between groups (P < 0.05); at 12 months post-surgery, both the vertical and horizontal dimensions of the peri-implant gap were significantly reduced compared to the immediate post-operative period, and the differences between different time points within the group were statistically significant (P < 0.05). In conclusion, for molars with chronic apical periodontitis and chronic periodontitis that meet the indications, immediate implant placement combined with non-submerged healing and no bone grafting in the jump space, provided that thorough debridement, precise implantation, and initial stability are ensured, offers reliable efficacy, fewer complications, and excellent bone preservation. Thus, this approach can be considered as a preferred clinical treatment option and worthwhile to be applied on a larger scale.
Copyright (c) 2026 Jing Luo, Li He, Jiao Zhang, Ru Guo, Qiaoyun Yang, Menglin Liao, Xiuhong Guo http://creativecommons.org/licenses/by/4.0
The Digits of the Lizard Podarcis muralis Heal But Do Not Regenerate After Topical Application of Hyaluronate and FGFs
Attempts to stimulate blastema formation and growth of digits in lizards have been carried out by topic treatments of a hyaluronate gel embedded with FGF1-2 on the amputated surface of digits. Six to ten topic coatings were applied on the stump surface during wound healing and after re-epithelialization, from 2 hours to 20 days post-amputation. Four lizards received injection of 5BrdU to evaluate cell proliferation. Histology of controls and treated digit stumps showed that a multilayered wound epidermis formed around 10-12 days post-amputation. Connective cells present underneath the wound epidermis gave rise to fibrocytes and numerous collagen fibrils after the second week post-amputation, turning the initial soft outgrowths of 0.3-0.5 mm into a solid and scaling scar at 32 days post-injury. Injection of 5BrdU revealed that cell proliferation was low in untreated and treated digit stumps at 12 and 32 days post-amputation, explaining the lack of growth of the initial digit outgrowth. The lack of regeneration may derive from limited penetration of hyaluronate-FGF. Cells activated on the stump surface are prevalently osteogenic, blocking digit regeneration. Next subcutaneous microinjections of hyaluronate-FGF gels might obtain a better stimulatory effect and induce formation of a growing digit outgrowth, as previously obtained for the limb.
Copyright (c) 2026 Alibardi Lorenzo http://creativecommons.org/licenses/by/4.0