Hematological Changes in an Ovine Model of Acute Myocardial Infarction

Abstract

To diagnose acute myocardial infarction, selected cardiac markers as well as hematological and biochemical indices have been studied in human being, however, rare investigations were done  on the values of hematologic analysis in an ovine model of myocardial infarction. To observe the change of the values in hematologic parameters in sheep, acute myocardial infarction was induced by ligation of left anterior descending coronary artery. For this purpose, ten healthy sheep were randomly divided into two group (5 each), the control group (group I; thoracotomy without myocardial infarction) and the experimental group (group II; with myocardial infarction). Animal in each group subjected for the hematologic analysis 1 week post-myocardial infarction. In comparison of hematologic analysis between two groups, the mean values of hemoglobin, white blood cell, red blood cell, platelets, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration showed a significant increase in myocardial infarction group (P<0.05). In conclusion, we could observe the alterations in early hematologic mean values in an ovine model of experimental acute myocardial infarction.