The Diagnostic and Prognostic Role of Serum MicroRNAs in Ovarian Cancer

Abstract

Aim

Summarize the research progress of serum miRNAs in clinical application for early diagnosis and prognosis of ovarian cancer. 

Methods

Review of the recently published literature was conducted. We selected reviews and clinical researches from different scientific societies.

Results

The abnormal expression of serum miRNAs has a certain clinical value in the

early diagnosis of ovarian cancer. Many miRNAs, which are involved in regulating ovarian cancer cell growth, migration, and drug resistance, are also closely related to the patients’ survival rate and affect the prognostic condition of the patients. So the serum miRNAs may be useful diagnostic and prognostic biomarkers.

Conclusions 

Studies have shown that serum miRNAs has the tumor specificity and high stability, enabling it has the potential for early diagnosis, prognosis and sensitivity to chemotherapy. However, the researches on serum miRNAs is still at the primary stage, further researches is needed for application of serum miRNAs in early diagnosis and prognosis of ovarian cancer.